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Postdoctoral Associate - Disney Lab

at The Scripps Research Institute

Posted: 6/24/2020
Job Status: Full Time
Job Reference #:

Job Description

Requisition Number 07683
Department Name: Chemistry - FL
Position Type: Full Time
Position Title Postdoctoral Associate - Disney Lab
Position Summary:

A Postdoctoral Associate is a direct pay individual in a Division 3 status. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Position Description

Beginning June 1, 2020, the Disney group in the Department of Chemistry at The Scripps Research Institute ( is seeking to hire multiple Postdoctoral Fellows in RNA Chemical Biology.

Scripps Research, one of the largest private non-profit biomedical research institutes in the world, comprises two linked campuses in Florida and California. New Fellows will conduct studies in drug discovery & development alongside over 200 internationally renowned faculty, contributing to Scripps’ reputation as the top-ranked stand-alone institute for biomedical research in the United States (Nature Index, 2019).

Lab Overview:
The Disney group is a chemical biology laboratory focused on developing rational approaches to design highly selective therapeutics from only genome sequence. Known for its prolific output and pioneering research culture, the group has furthered advancements in annotating RNA structure from sequence alongside several novel technologies created in-house. The laboratory’s targeting of RNA by small molecules, an ambitious and highly focused enterprise in pursuit of chemical probe and lead medicine development, is summarized in the Journal of the American Chemical Society (2019) 141:6776-6790.

Other representative publications from the Disney group include:

* Studying disease mediated by RNA repeat expansions that cause genetically defined ALS and dementia:
oNeuron (2014) 83:1043-50
oCell Chemical Biology (2019) 26:179-190

* Targeted RNA degradation and related technologies:
oProceedings of the National Academy of Sciences USA (2020) 117:2406-2411
oJournal of the American Chemical Society (2018) 140:6741-6744
oProceedings of the National Academy of Sciences USA (2019) 116:7799-7804.
oNature Chemical Biology (2017) 13:188-193

* Precision targeted therapeutics for difficult-to-treat cancers and other diseases:
oJournal of the American Chemical Society (2019) 141:2960-2974
oCell Chemical Biology (2018) 25:1086-1094
oProceedings of the National Academy of Sciences USA (2016) 113:5898-903
oProceedings of the National Academy of Sciences USA (2020) 117:1457-1467.

Our Commitment: The Disney group is highly committed to each individual’s professional development during his or her time in the lab. A high impact research project and training plan to support the achievement of short-term as well as long-term career goals is customized for each student.

Contact: Applicants should send their CV and have three letters of reference sent on their behalf directly to Prof. Matthew Disney at

Location: Florida
Additional Information:
Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry. Highly motivated candidates possessing a strong academic track-record, a high-impact publication list, a team-player mentality, and an interest in targeting the RNA world are poised for success in the group. The Disney group employs a broad range of experimental techniques, and thus a diverse set of research skills is preferable and a willingness to learn new methods is essential.

Preferred Qualifications:

Preference will be given to candidates with strong skills in RNA biology techniques, molecular biology, and biochemical methods. Previous experience with RNA-seq data analysis, DNA encoded library design and screening, and structure-based design is also desirable.

Job Closing Date:
Open Until Filled Yes
Job Posting Category Postdoctoral
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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